1. Recent studies have contended that Pol? may synthesize the leading strand . 2. The leading strand receives one RNA primer while the lagging strand receives several. 3. In most bacteria majority of the genes are encoded in the leading strand . 4. Yeast studies have shown that Pol? can proofread Pol? errors on the leading strand . 5. Next, DNA polymerase III ( green ) produces the leading strand copy ( red ). 6. On the leading strand this route is continuous, but on the lagging strand it is discontinuous. 7. Leading strand synthesis then proceeds continuously, while the DNA is concurrently unwound at the replication fork.8. This means that nucleotide synthesis on the leading strand naturally occurs in the 5'to 3'direction. 9. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. 10. This polymerase synthesizes leading strand DNA in eukaryotes . ( Thought to form an asymmetric dimer with DNA polymerase delta .)
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